• Lu group holiday party 2019

Welcome!

The Lu Group’s research interests lie in the interface between chemistry and biology. We are developing innovative chemical approaches to gain deeper insight into biological structures and functions, while also taking advantage of recently developed biological tools to advance all areas in chemistry, including analytical, inorganic, organic, physical and materials chemistry. Specific projects of current interests are:

1. Biosynthetic Inorganic Chemistry

Computational design and directed evolution of artificial metalloenzymes as environmentally benign biocatalysts for renewable energy generation and pharmaceutical drug syntheses.

2. Biocatalysis and Synthetic Biology

Engineer biocatalysts to address challenges in synthetic organic chemistry and applications of novel biocatalysts in synthetic biology for biomass conversion and valuable products generation in high yield and good selectivity.

3. Bioanalytical Chemistry

Design and selection of sensors and imaging agents for metal ions, metabolites and glycoRNAs to advance metallomics, metabolomics and glycomics for medical diagnosis, imaging and therapy in neurodegenerative and infectious diseases and cancers.

4. Functional DNA Nanotechnology

Using DNA for encoded synthesis and directed assembly of nanomaterials, as well as the applications of these nanomaterials as theranostic agents for early detection of diseases such as cancers and targeted drug delivery.

5. Gene Editing/Therapy

Developing novel gene-editing methods to improve sequence fidelity and gene target accessibility.
 

Recent News

2024 December | The Lu group won the Lead Detect Prize together with GlucoSentient, Inc.

2024 December | Congratulations to Yunling, who will start her independent career as an assistant professor in the Department of Chemistry at St. Mary’s College of Maryland!

2024 December | Congratulations to Yiming, who will start her independent career as an assistant professor in the Department of Chemistry from Haverford College!

2024 August | Mandira’s work on brain imaging with fluorescence sensors using exosome delivery has been covered by ACS Newsroom.

2024 August | The Lu group, along with the groups of Thomas Cundari, Andy Ellington, Kami Hull and Mike Rose, have received a Catalyst for Discovery program grant from the Welch Foundation.

2024 May | Congratulations, Yiwei, for receiving the Summer 2024 Chemistry Department Research Fellowship!

2024 April | Whitney has won the prestigious P.E.O. Scholar Award. Congratulations, Whitney!

2024 March | The Lu group is among the winners of Phase I of the Lead Detect Prize.

2024 March | The Lu group has become an associate member of The Acquired Resistance to Therapy Network (ARTNet). We are working with Dr. Boyi Gan and others at the MD Anderson Cancer Center on developing imaging probes to gain mechanistic insights into ferroptosis and cuprotosis and using the insights to design better ferroptosis- and cuprotosis-inducing anti-cancer drugs.

2024 March | The Lu group has received a grant from CPRIT to decipher iron redox cycles in ferroptosis-based cancer therapy.

2023 August | Dr. Lu has become a member of the Institute for Neuroscience.

2023 April | Yuan and Weijie’s Nature Biotechnology paper on glycoRNA imaging got featured in CNS News.